Shark chondroitin sulfate ifite isuku nyinshi ni ikintu cyingenzi mu buvuzi rusange
Chondroitin sulfate (CS) ni glycosaminoglycan y'ingenzi ifitanye isano na poroteyine kugira ngo ikore proteoglycans.Ikwirakwizwa cyane muri matrice idasanzwe hamwe nubuso bwimiterere yinyama zinyamanswa, kandi nikintu cyingenzi mubice bihuza inyamanswa, cyane cyane muri karitsiye.Imiterere shingiro ya chondroitine sulfate ikorwa muguhinduranya aside ya D-glucuronic na N-acetylgalactosamine na glycosidic, ibyo bikaba bihuzwa nigice cyibanze cya poroteyine kugirango bigire imiterere igoye ya proteoglycan.
Sulfate ikomoka kuri Shark ikomoka kuri Shark ni imwe muri zo, ikaba ari aside mucopolysaccharide acide yateguwe kuva mu nyama za karitsiye.Bigaragara nkifu yera cyangwa yera isa nifu, nta mpumuro nziza, uburyohe butabogamye.Chondroitin shark sulfate ni kimwe mu bintu by'ingenzi bigize inyama z’inyamabere zihuza inyamaswa z’inyamabere, kandi iboneka cyane muri karitsiye, amagufwa, imitsi, ligaments, sarcolemma, hamwe n'inkuta z'amaraso.
Ikora nko kugumana no gushyigikirwa muri karitsiye.Kunywa mu rugero rwa sulfate ya chondroitine birashobora gufasha kugumana ingirabuzimafatizo, kugabanya kubyimba no kubabara, kunoza imikorere idahwitse, no kugira umutekano mwinshi.Bikunze gukoreshwa bifatanije na glucosamine, uruvange rutezimbere cyane mububabare butagereranywa kandi bukabije muri osteoarthritis kandi butera kolagen nshya na proteoglycans muri chondrocytes.
| izina RY'IGICURUZWA | Shark Chondroitin Sulfate Soidum |
| Inkomoko | Inkomoko ya Shark |
| Ubuziranenge | USP40 Bisanzwe |
| Kugaragara | Umweru kugeza ifu yera |
| Numero ya CAS | 9082-07-9 |
| Inzira yumusaruro | enzymatique hydrolysis inzira |
| Ibirimo poroteyine | ≥ 90% na CPC |
| Gutakaza Kuma | ≤10% |
| Ibirimo poroteyine | ≤6.0% |
| Imikorere | Inkunga yubuzima ihuriweho, Cartilage nubuzima bwamagufwa |
| Gusaba | Ibiryo byongera ibiryo muri Tablet, Capsules, cyangwa ifu |
| Icyemezo cya Halal | Nibyo, Halal Yaragenzuwe |
| Imiterere ya GMP | NSF-GMP |
| Icyemezo cyubuzima | Nibyo, icyemezo cyubuzima kirahari kubikorwa byemewe |
| Ubuzima bwa Shelf | Amezi 24 uhereye igihe yatangiriye |
| Gupakira | 25KG / Ingoma, Gupakira Imbere: Kabiri PE BAGS, Gupakira hanze: Ingoma y'impapuro |
| INGINGO | UMWIHARIKO | UBURYO BWO Gupima |
| Kugaragara | Ifu yera ya kirisiti | Biboneka |
| Kumenyekanisha | Icyitegererezo cyemeza hamwe nububiko bwibitabo | Na NIR Spectrometer |
| Imirasire ya infragre ya sisitemu igomba kwerekana maxima gusa muburebure bumwe nkubwa chondroitin sulfate sodium WS | Byerekanwa na FTIR | |
| Ibigize disaccharide: Ikigereranyo cyibisubizo byimpanuka kuri △ DI-4S na △ DI-6S ntabwo kiri munsi ya 1.0 | Enzymatic HPLC | |
| Guhinduranya neza: Kuzuza ibisabwa kugirango uhindurwe neza, kuzunguruka mu bizamini byihariye | USP781S | |
| Suzuma (Odb) | 90% -105% | HPLC |
| Gutakaza Kuma | <12% | USP731 |
| Poroteyine | <6% | USP |
| Ph (1% H2o Igisubizo) | 4.0-7.0 | USP791 |
| Kuzenguruka byihariye | - 20 ° ~ -30 ° | USP781S |
| Ibisigisigi kuri Ingition (Base yumye) | 20% -30% | USP281 |
| Ibisigisigi bihindagurika | NMT0.5% | USP467 |
| Sulfate | ≤0.24% | USP221 |
| Chloride | ≤0.5% | USP221 |
| Ibisobanuro (5% H2o Igisubizo) | <0.35@420nm | USP38 |
| Amashanyarazi meza | NMT2.0% | USP726 |
| Imipaka ntanimwe idasanzwe | ＜ 10% | Enzymatic HPLC |
| Ibyuma biremereye | ≤10 PPM | ICP-MS |
| Umubare wuzuye | 0001000cfu / g | USP2021 |
| Umusemburo & Mold | ≤100cfu / g | USP2021 |
| Salmonella | Kubura | USP2022 |
| E.Coli | Kubura | USP2022 |
| Staphylococcus Aureus | Kubura | USP2022 |
| Ingano ya Particle | Guhindura ukurikije ibyo usabwa | Mu nzu |
| Ubucucike bwinshi | > 0.55g / ml | Mu nzu |
Ubwa mbere, chondroitin sulfate ni glycosaminoglycan iboneka cyane kuri matrice idasanzwe yinyama.Mu magufa, usanga ahanini muri peripheri ya chondrocytes kandi nikintu cyingenzi kigize matrice idasanzwe.Ibintu bifasha karitsiye kubona amazi nintungamubiri, bityo bikagumana ububobere kandi bworoshye, kandi bigafasha gukomeza imikorere isanzwe yingingo.
Icya kabiri, ingaruka zifatika za chondroitine sulfate ni ingenzi cyane kuri karitsiye.Irashobora guhuza molekile zamazi, guhumeka molekile zamazi muri molekile ya proteoglycan, kubyimba karitsiye no kongera ubwinshi bwamazi ya synovial mumyanya ihuriweho, gusiga no gushyigikira ingingo.Muri ubu buryo, ingingo irashobora kugabanya guterana n'ingaruka iyo yimutse, kugirango ingingo ishobora kugenda cyane mubwisanzure.
Hanyuma, chondroitin sulfate nayo ikora mubwubatsi bwamagufwa.Abashakashatsi bateguye hydrogène ikomatanya ishingiye kuri sulfate ya chondroitine, ihuza ubwigenge ion idasanzwe kandi igatera amagufwa ya biomineralisation, bityo bikazamura ubushobozi bwo kuvugurura amagufwa.Ibi bifite akamaro gakomeye kubaga amagufwa yubuvuzi nko gusana amagufwa no guhimba amagufwa.
1. Guteza imbere ubuzima buhuriweho: Chondroitin sulfate ni kimwe mu bintu by'ingenzi bigize karitsiye, ishobora gufasha ingirabuzimafatizo kugira ngo igumane ubworoherane n'amazi, bityo bikomeze imikorere isanzwe y'ingingo.Iyo wongeyeho sulfate ya chondroitine, irashobora guteza imbere gusana no kuvugurura karitsiye ya articular, bityo bikadindiza inzira yo kwangirika.
2. Kugabanya ububabare bufatanye: chondroitin sulfate irashobora kugabanya igisubizo cyumuriro mu ngingo, kugabanya imbaraga za synovium ihuriweho, hanyuma bikagabanya ububabare bufatanye.Ibi bifite ingaruka zikomeye zo kugabanya ububabare kubarwayi bafite indwara zifatika nka artite.
3. Kunoza urujya n'uruza: Chondroitin sulfate itezimbere kugenda no guhinduka kwingingo zongera amavuta hamwe no kugabanya guterana hamwe.Ibi bituma urugingo rugenda neza mugihe cyo kugenda, bikagabanya ingorane ziterwa no gukomera hamwe cyangwa kugenda kugarukira.
4. Kurinda karitsiye: Chondroitin sulfate irashobora kubuza kwangirika kwa karitsiye, kandi igateza imbere no gusohora chondrocytes, kugirango igire uruhare mukurinda karitsiye.Ibi bifasha gutinza inzira yo gusaza hamwe no kwangirika.
1. Gukiza ibikomere no gusana uruhu: Chondroitin sulfate igira uruhare runini mugikorwa cyo gukira ibikomere.Irashobora guteza imbere kuvugurura no gusana ingirangingo z'imvune, kunoza ubuhanga no gukomera k'uruhu, kandi bigafasha kugabanya inkovu.Kubwibyo, chondroitin sulfate ifite uburyo bushoboka muburyo bwo kubaga, kuvura gutwika no gusana uruhu.
2. Inganda zo kwisiga: Bitewe nuburyo bwiza bwo gutanga amazi hamwe ningaruka zo gusaza, sulfate ya chondroitine nayo ikoreshwa cyane mubikorwa byo kwisiga.Irashobora kongerwaho mubicuruzwa byita kuruhu nkibintu bitanga amazi, bifasha kugumana ubushuhe bwuruhu no kunoza uruhu rworoshye.Byongeye kandi, chondroitin sulfate irashobora kandi kubuza umusaruro wa radicals yubuntu, kugabanya umuvuduko wo gusaza kwuruhu, kandi bigatuma uruhu ruba ruto kandi rukagira ubuzima bwiza.
3. Ubuhanga bwimyenda nubuvuzi bushya: Mu rwego rwubwubatsi bwa tissue nubuvuzi bushya, sulfate ya chondroitin ikoreshwa nkigice cyo kubaka ibikoresho bya biomimetike.Irashobora guhuzwa nibindi binyabuzima kugirango ikore scafolds ifite imiterere nimirimo yihariye yo gusana cyangwa gusimbuza ingirangingo n'ingingo byangiritse.Biocompatibilité na bioactivite ya chondroitin sulfate ituma iba umukandida wingenzi mubijyanye nubwubatsi bwa tissue.
4. Ingaruka za antitumor: Mu myaka yashize, ubushakashatsi bwerekanye ko sulfate ya chondroitine nayo ifite ubushobozi bwa antitumor.Irashobora kubuza gutangira ibibyimba no gutera imbere muguhindura imikurire, itandukaniro hamwe na apoptotique ya selile yibibyimba.Nubwo ubushakashatsi bujyanye nubu buracyari mubyiciro byambere, biteganijwe ko hakoreshwa chondroitine sulfate mu rwego rwo kurwanya ibibyimba.
Chondroitin sulfate na glucosamine sulfate ntabwo ari ubwoko bumwe.Hariho itandukaniro mubyo bahimbye, gukoresha nuburyo bwibikorwa.
Chondroitin sulfate ni glycosaminoglycan ifite ibikorwa bitandukanye byibinyabuzima, harimo na lipide igenga ndetse ningaruka zo kurwanya inflammatory.Ikoreshwa cyane mu kuvura osteoarthritis kandi irashobora kugabanya abunzi batera umuriro hamwe na apoptotique, mugihe icyarimwe igabanya umusaruro wa cytokine ikongora, iNOS na MMPs.Byongeye kandi, sulfate ya chondroitine nayo igira uruhare runini mukurinda no gusana karitsiye ya artique, ifasha karitsiye kurwanya imihangayiko ikabije mubihe bitandukanye byo gupakira ituma tissue irwanya kandi yoroheje.
Kandi glucosamine sulfate ni urundi ruganda rukomeye, rukoreshwa cyane cyane mu gukumira no kuvura ubwoko butandukanye bwa osteoarthritis, nk'amavi hamwe n'ikibuno.Ikora kuri karitsiye ya articular, mugukangura chondrocytes kugirango itange proteoglycans ifite imiterere isanzwe ya polysome, itezimbere ubushobozi bwo gusana chondrocytes, ibuza imisemburo ya karitsiye yangiza nka kolagenase na fosifolipase A2, kandi irashobora kubuza gukora radicals yubusa ya selile yangiritse, bityo bigatinda. inzira ya pathologiya ya osteoarthritis niterambere ryindwara, kunoza ibikorwa bihuriweho, kugabanya ububabare.
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