Kolagen ni ubwoko bwa poroteyine yera, idasobanutse, idafite amashami ya fibrous, ibaho cyane cyane mu ruhu, amagufwa, karitsiye, amenyo, imitsi, ligaments hamwe nimiyoboro yamaraso yinyamaswa.Ni poroteyine yingenzi cyane yubaka ingirabuzimafatizo, kandi igira uruhare mu gushyigikira ingingo no kurinda umubiri.Mu myaka yashize, hamwe n’iterambere ry’ikoranabuhanga ryo gukuramo kolagen hamwe n’ubushakashatsi bwimbitse ku miterere n'imiterere yabyo, imikorere y’ibinyabuzima ya hydrolysate ya kolagen na polypeptide yamenyekanye buhoro buhoro.Ubushakashatsi nogukoresha kwa kolagen byahindutse ahantu h’ubushakashatsi mubuvuzi, ibiryo, amavuta yo kwisiga nizindi nganda.
- Gukoresha kolagen mubicuruzwa byibiribwa
- Gukoresha kolagen muri calcium Yongeyeho ibicuruzwa
- Gukoresha kolagen mugaburira ibicuruzwa
- Ibindi Porogaramu
Kolagen irashobora kandi gukoreshwa mubiryo.Nko mu kinyejana cya 12 MutagatifuHilde-gard wa Bingen yasobanuye ikoreshwa ry'isupu y'inyana nk'umuti wo kuvura ububabare bw'ingingo.Igihe kinini, ibicuruzwa birimo kolagen byafatwaga nkibyiza kubice.Kuberako ifite ibintu bimwe na bimwe bikoreshwa mubiryo: urwego rwibiryo rusanzwe rwera mumiterere, yoroshye muburyohe, urumuri muburyohe, byoroshye kurigogora.Irashobora kugabanya amaraso triglyceride na cholesterol, kandi ikongera ibintu byingenzi byingenzi mumubiri kugirango bikomeze muburyo busanzwe.Nibiryo byiza byo kugabanya lipide yamaraso.Byongeye kandi, ubushakashatsi bwerekanye ko kolagen ishobora gufasha kurandura aluminiyumu mu mubiri, kugabanya ikwirakwizwa rya aluminiyumu mu mubiri, kugabanya ingaruka za aluminiyumu ku mubiri w’umuntu, kandi bigatera imikurire y’imisatsi n’imisatsi ku rugero runaka.Ubwoko bwa II kolagen ni poroteyine nyamukuru muri karitsiye ya articular bityo rero ishobora kuba autoantigen.Ubuyobozi bwo mu kanwa bushobora gutera T selile kubyara ubudahangarwa bw'umubiri no gukumira indwara ziterwa na autoimmune T selile.Kolagen polypeptide nigicuruzwa gifite igogorwa ryinshi kandi ryinjira kandi rifite uburemere bwa 2000 ~ 30000 nyuma ya kolagen cyangwa gelatine yangijwe na protease.
Imico imwe n'imwe ya kolagen ituma ikoreshwa nkibintu bikora nibigize intungamubiri mubiribwa byinshi bifite ibyiza bitagereranywa nibindi bikoresho: imiterere ihindagurika ya macromolecules ya kolagen no kubaho kwa kristu ituma igira ituze ryumuriro;Imiterere isanzwe ya fibre fibre ya kolagen ituma ibikoresho bya kolagen byerekana gukomera nimbaraga, bikwiranye no gutegura ibikoresho bya firime yoroheje.Kuberako urunigi rwa molekile ya kolagen irimo umubare munini wamatsinda ya hydrophilique, bityo ifite ubushobozi bukomeye bwo guhuza namazi, bigatuma kolagen ishobora gukoreshwa nkuzuza na geles mubiryo.Kolagen yaguka mubitangazamakuru bya acide na alkaline, kandi uyu mutungo urakoreshwa muburyo bwo kuvura mugutegura ibikoresho bishingiye kuri kolagen.
Ifu ya kolagen irashobora kongerwamo ibicuruzwa byinyama kugirango bigire ingaruka ku nyama zinyama ndetse nimiterere yimitsi nyuma yo guteka.Ubushakashatsi bwerekanye ko kolagen ari ingenzi mu gushiraho inyama mbisi n’inyama zitetse, kandi ko uko ibintu byinshi bya kolagene bigenda, niko inyama zigora.Kurugero, gutanga amafi bikekwa ko bifitanye isano no kwangirika kwubwoko bwa V kolagen, kandi gusenyuka kwa fibre ya peripheri ya kolagen iterwa no gusenyuka kwa peptide bikekwa ko arimpamvu nyamukuru itera imitsi.Mugusenya hydrogène muri molekile ya kolagen, imiterere yumwimerere ya superhelix irasenywa, hanyuma gelatine ifite molekile ntoya hamwe nuburyo bworoshye irekurwa, idashobora kuzamura ubwiza bwinyama gusa ahubwo inazamura agaciro kayo ikoreshwa, itume igira ibyiza ubuziranenge, kongera poroteyine, uburyohe bwiza nimirire.Ubuyapani nabwo bwateje imbere inyamaswa zo mu bwoko bwa kolagene nkibikoresho fatizo, hydrolyz na enzymes ya kolagen hydrolytique, inashyiraho uburyo bushya hamwe n’inyungu, bidafite uburyohe bwihariye, ariko kandi bushobora kuzuza igice cya aside amine.
Hamwe nubwoko butandukanye bwibicuruzwa bya sosiso mubicuruzwa byinyama bigira uruhare runini, ibicuruzwa bisanzwe birabura cyane.Abashakashatsi barimo gukora kugirango bategure ubundi buryo.Ibikoresho bya kolagen, byiganjemo kolagen, ubwabyo bikungahaye ku ntungamubiri kandi bifite proteyine nyinshi.Mugihe amazi namavuta bigenda bishonga kandi bigashonga mugihe cyo kuvura ubushyuhe, kolagen igabanuka hafi kurwego rumwe ninyama, ubuziranenge ntakindi kintu cyo gupakira kiribwa wasangaga gifite.Byongeye kandi, kolagen ubwayo ifite umurimo wo guhagarika imisemburo kandi ifite antioxydeant, ishobora kuzamura uburyohe nubwiza bwibiryo.Guhangayikishwa nibicuruzwa bigereranwa nibiri muri kolagen, mugihe umutwaro uringaniye.
Kolagen nikintu cyingenzi cyamagufa yabantu, cyane cyane karitsiye.Kolagen ni nkurubuga rwimyobo mito mumagufwa yawe afashe kuri calcium igiye kubura.Hatariho urushundura rwuzuyemo ibyobo bito, ndetse na calcium irenze yabura kubusa.Acide iranga aminide ya kolagen, hydroxyproline, ikoreshwa muri plasma yo gutwara calcium mu ngirabuzimafatizo.Kolagen mu ngirabuzimafatizo ikora nk'igikoresho gihuza hydroxyapatite, igahuza igice kinini cy'amagufwa.Intangiriro ya osteoporose nuko umuvuduko wa synthesis ya kolagen idashobora kugendana nibikenewe, mu yandi magambo, igipimo cyo gukora kolagen nshya kiri munsi ya mutation cyangwa gusaza kwa kolagen ishaje.Ubushakashatsi bwerekanye ko mugihe nta kolagene ihari, nta calcium yuzuye ishobora kwirinda osteoporose.Kubwibyo, calcium irashobora gusya kandi igatwarwa vuba mumubiri, kandi irashobora kubikwa mumagufa byihuse gusa iyo gufata calcium ihagije ya kolagen.
Polimeri ya kolagen-pvp (C-PVP) yateguwe nigisubizo cya kolagen na polyvinylpyrrolidone muri buffer ya citric aside ntabwo ikora neza gusa, ahubwo ifite umutekano mukwongera amagufwa yakomeretse.Nta lymphadenopathie, kwangirika kwa ADN, cyangwa indwara ziterwa na metabolike y'umwijima n'impyiko bigaragarira no mu gihe kirekire cyo kuyobora bikomeje, hatitawe ku bigeragezo cyangwa ku mavuriro.Ntanubwo itera umubiri wumuntu gukora antibodies zirwanya C-PVP.
| izina RY'IGICURUZWA | Peptide ya kolagen |
| Numero ya CAS | 9007-34-5 |
| Inkomoko | Guhisha Bovie, Ibyatsi bya Federasiyo ya bovine, uruhu rwamafi nubunini, amafi ya karitsiye |
| Kugaragara | Umweru kugeza kuri Powder yera |
| Inzira yumusaruro | Enzymatique Hydrolysis yo gukuramo |
| Ibirimo poroteyine | ≥ 90% kuburyo bwa Kjeldahl |
| Gukemura | Ako kanya kandi Byihuse mumazi akonje |
| Uburemere bwa molekile | Hafi ya Dalton |
| Bioavailability | Bioavailability |
| Urujya n'uruza | Inzira nziza |
| Ibirungo | ≤8% (105 ° mu masaha 4) |
| Gusaba | Ibicuruzwa byita ku ruhu, ibicuruzwa byitaweho, ibiryo, ibikomoka ku mirire ya siporo |
| Ubuzima bwa Shelf | Amezi 24 uhereye igihe yatangiriye |
| Gupakira | 20KG / BAG, 12MT / 20 'Ibirimo, 25MT / 40' Ibikoresho |
Ifu ya kolagen yo kugaburira ni igicuruzwa cya poroteyine gitunganywa n’ikoranabuhanga ry’umubiri, imiti cyangwa ibinyabuzima ukoresheje ibikomoka ku mpu, nkibishishwa by’uruhu n’inguni.Imyanda ikomeye ikorwa na homogenizing hamwe no gukata nyuma yo gukanika hamwe hamwe bita imyanda yo mu bwoko bwa tannery, kandi ibintu nyamukuru byumye ni kolagen.Nyuma yo kuvurwa, irashobora gukoreshwa nkinyamanswa ikomoka ku nyamaswa ikomoka ku nyamaswa kugira ngo isimbuze cyangwa isimbuze igice cy’amafunguro y’amafi yatumijwe mu mahanga, ashobora gukoreshwa mu gutanga ibiryo bivanze kandi bivanze hamwe n’ingaruka nziza yo kugaburira kandi inyungu z’ubukungu.Intungamubiri za poroteyine ni nyinshi, zikungahaye ku bwoko burenga 18 bwa aside amine, irimo calcium, fosifore, fer, manganese, seleniyumu n'ibindi bintu by'amabuye y'agaciro, kandi bifite uburyohe bwa aromatic.Ibisubizo byerekana ko ifu ya hydrolyzed ya kolagen ishobora gusimbuza igice cyangwa rwose ifunguro ryamafi cyangwa ifunguro rya soya mumirire yingurube zikura-zirangiza.
Ikizamini cyo gukura no gusya nacyo cyakozwe kugirango harebwe isimburwa rya kolagen mu ifunguro ry’amafi mu biryo byo mu mazi.Igogorwa rya kolagene muri allogynogenetic crucian carp ifite impuzandengo yumubiri wa 110g yagenwe na algorithm.Ibisubizo byerekanaga ko kolagen yari ifite igipimo kinini cyo kwinjiza.
Ihuriro riri hagati yo kubura umuringa wimirire hamwe na kolagen mumitima yimbeba byizwe.Ibisubizo by'isesengura rya SDS-PAGE hamwe na Coomassie ibara ry'ubururu ryerurutse ryerekanaga ko ibimenyetso byongera imiterere ya kolagen yahinduwe bishobora guhanura ibura ry'umuringa.Kubera ko fibrosis yumwijima igabanya proteyine, irashobora kandi guhanurwa mugupima urugero rwa kolagen mumwijima.Anoectochilusformosanus ikuramo amazi (AFE) irashobora kugabanya fibrosis yumwijima iterwa na CCl4 no kugabanya umwijima wa kolagen.Collagen nayo ni igice cyingenzi cya sclera kandi ni ingenzi cyane kumaso.Niba umusaruro wa kolagen muri sclera ugabanuka no kwangirika kwayo kwiyongera, birashobora gutera myopiya.
Ibyerekeye Twebwe
Yashinzwe mu mwaka wa 2009, Hejuru ya Biopharma Co, Ltd.Uruganda rwacu rukora rufite ubuso bwuzuye9000metero kare kandi ifite ibikoresho4Yeguriwe Imirongo ikora yikora.Amahugurwa yacu ya HACCP yakubiyemo agace kegereye5500㎡n'amahugurwa yacu ya GMP akubiyemo ubuso bungana na 2000 ㎡.Uruganda rwacu rwo gukora rwateguwe hamwe nubushobozi bwumwaka wa3000MTIfu ya kolagen nyinshi Ifu na5000MTIbicuruzwa bya Gelatin.Twohereje hanze ifu ya kolagen nini na Gelatin hirya no hinoIbihugu 50kwisi yose.
Serivise yumwuga
Dufite itsinda ryabacuruzi babigize umwuga ritanga igisubizo cyihuse kandi cyukuri kubibazo byawe.Turagusezeranya ko uzakira igisubizo kubibazo byawe mugihe cyamasaha 24.
Igihe cyo kohereza: Mutarama-06-2023